Clinical Trials / Key Publications
Key Publications
Our research is published in leading scientific journals, sharing evidence from our clinical trials and demonstrating the potential of our breath-based cancer detection method. These papers reflect years of collaboration between scientists, clinicians, and technology experts to advance early detection.
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Our Research & Clinical Evidence
Our scientific foundation is built on rigorous clinical research, peer-reviewed validation, and a novel integration of biology and technology. The following key publications present our innovative approach to breath-based cancer detection, combining the olfactory power of trained canines with artificial intelligence.
These studies, published in top-tier journals, present data from our clinical trials evaluating the effectiveness of our non-invasive method in detecting multiple cancer types from exhaled breath, a method that is redefining what early detection can look like.
Scientific Reports (Nature Portfolio), 2024
Title
Non-invasive multiple cancer screening using trained detection canines and artificial intelligence: a prospective double-blind study
Published in
Scientific Reports (Nature Portfolio), Volume 14, Article 28204, November 2024
Authors
E. Half, A. Ovcharenko, R. Shmuel, S. Furman-Assaf, M. Avdalimov, A. Rabinowicz, N. Arber
Study Type
Prospective, double-blind, 1,386-participant clinical trial across 3 Israeli medical centers
Summary
This landmark publication reports on SpotitEarly’s 1,386-participant double-blind clinical trial ("The Rainbow Study"). The study demonstrated 93.9% sensitivity and 94.3% specificity for four major cancers: breast, lung, colorectal, prostate, through a novel bio-hybrid platform combining canine scent detection with AI-powered behavioral analysis. It also demonstrated 94.8% sensitivity for early-stage cancers (Stage 0–2) and was able to detect 14 additional cancer types outside the training panel with 81.8% sensitivity.
The trial confirms the feasibility and scalability of SpotitEarly’s approach and sets the stage for broader clinical deployment.
Cancers, 2025
Title
Innovative Approaches to Early Detection of Cancer-Transforming Screening for Breast, Lung, and Hard-to-Screen Cancers
Published in
Cancers, Volume 17, Article 1867, June 2025
Authors
S. Madar, R.E. Amor, S. Furman-Assaf, E. Friedman
Study Type
Peer-reviewed review article
Summary
This comprehensive review explores emerging non-invasive cancer screening technologies, with a focus on SpotitEarly’s breath-based test. It highlights how volatile organic compounds (VOCs) in exhaled breath, detected via trained canines and analyzed with AI, can enable multi-cancer detection, including for cancers with limited or no routine screening options.
The paper contextualizes SpotitEarly’s model alongside liquid biopsy and electronic nose technologies, underscoring its potential to enhance compliance, reduce barriers, and reach underserved populations.